منابع مشابه
Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae
How alternative chromatin-based regulatory states can be made stable and heritable in order to provide robust epigenetic memory is poorly understood. Here, we develop a stochastic model of the silencing system in Saccharomyces cerevisiae that incorporates cooperative binding of the repressive SIR complex and antisilencing histone modifications, in addition to positive feedback in Sir2 recruitme...
متن کاملYes Sir, no Sir, not much difference Sir.
OBJECTIVE To assess whether making the sender's knighthood explicit in a series of letters would have any detectable effect on the response. DESIGN A random sequence was generated by flipping a coin to determine whether a letter would have 'Sir Iain Chalmers' or 'Iain Chalmers' typed under the signature. This sequence was prepared independently of the preparation of an alphabetic list of the ...
متن کاملSir- and silencer-independent disruption of silencing in Saccharomyces by Sas10p.
A promoter fusion library of Saccharomyces cerevisiae genes was used to exploit phenotypes associated with altered protein dosage. We identified a novel gene, SAS10, by the ability of Sas10p, when overproduced, to disrupt silencing. The predicted Sas10p was 70,200 kD and strikingly rich in charged amino acids. Sas10p was exclusively nuclear in all stages of the cell cycle. Overproduction of Sas...
متن کاملDear Sir
Dr. David Mermin's review of Alan Sokal's "Beyond the hoax" (Science wars revisited, N. David Mermin, Nature 454, 276-277, 17 July 2008) makes some good points, but the overall thrust is unnecessarily and unfairly negative. Anyone who has not read Dr. Sokal's book may come away with the impression that he has spent the whole book rehashing stale debates and attacking articulate and scientifical...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2001
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20010126-02